MET-VASC En Los Medios

MET-VASC in the media

Eating healthy can reverse vascular damage associated to obesity (article in Spanish).

24/11/23

Research published in the prestigious journal Acta Physiologica provides new evidence on the benefits of healthy dietary habits in the control of cardiovascular diseases. The study describes how a dietary intervention can achieve beneficial effects, both functional and molecular, similar to those provided by pharmacological treatment.

The role of diet in its prevention is well known; however, as Beatriz Somoza explains, “this work demonstrates how the alteration of the AMPK/CREB/HO-1 pathway, responsible for the endothelial damage associated with obesity, can constitute a new therapeutic target. Dietary intervention activates this pathway, demonstrating the efficacy of the non-pharmacological approach in the context of obesity-associated vascular damage.” On the other hand, Dr. Somoza highlights the fact that a healthy diet maintained over time “allows not only to lose weight, but also to significantly improve glucose tolerance, which can delay or even prevent the development of type 2 diabetes mellitus, among other metabolic alterations.”

Approaching hypertension from the pharmacy (article in Spanish)

06/11/23

Compound 21 (C21), the first selective, orally active angiotensin II receptor type 2 agonist, is currently in phase II clinical investigation for the treatment of idiopathic pulmonary fibrosis. However, numerous preclinical research studies carried out in animals have demonstrated the therapeutic potential of this molecule in many other pathologies. On the one hand, C21 has an important vasodilator and natriuretic effect, so it has antihypertensive properties. In fact, although the efficacy of this compound in monotherapy is controversial, several studies have shown that treatment with C21 potentiates the antihypertensive effect of angiotensin II receptor.

On the other hand, beneficial effects of this compound at the metabolic level have also been described, including weight loss and a decrease in the amount of adipose tissue, as well as an improvement in insulin sensitivity and a decrease in plasma lipids.

Molecular effects of dietary interventions-A clinical perspective.

06/11/23

A new target against obesity and its associated cardiovascular diseases has been discovered (article in Spanish)

23/10/23

How obesity damage blood vessels (article in Spanish)

23/11/21

Compound 21, a new drug useful in the prevention of obesity-related vascular damage. (Article in Spanish)

16/06/21

The research provides evidence about the alterations that a high-fat diet causes in the signaling of the type 2 angiotensin II endothelial receptor (R-AT2). This receptor, important in the regulation of arterial tone by maintaining the functionality of the vascular endothelium through the activation of nitric oxide synthesis, carries out its functions through the formation of dimers with the bradykinin receptor (R-B2) and the Mas receptor (R-Mas). However, obesity induces alterations in the communication between these receptors, leading to the development of vascular damage.

A study suggests that vitamin E could reduce the risk of malformations in babies born to mothers with pregestational obesity. (Article in Spanish)

20/10/21

Supplementation with vitamin E could reduce the risk of babies born to mothers with pregestational obesity being born with malformations. This is the conclusion of a study published in the journal ‘Antioxidants’, developed and led by researchers from the Metabolism and Vascular Function Group (MET-VASC) of the CEU San Pablo University, in collaboration with Harvard University in Boston (USA).

Researchers at CEU develop a new technique that will help control obesity. (Article in Spanish)

20/10/21

Professors from the Department of Biochemistry and Molecular Biology at the Faculty of Pharmacy of the CEU San Pablo University, Martín Alcalá, María Calderón-Domínguez, and Marta Viana, have participated in the development of a new technique to measure the production and utilization of energy in brown adipose tissue, a key organ in obesity due to its ability to oxidize fat and dissipate energy as heat. This method, published in the scientific journal ‘Advanced Science’, improves the accuracy of previous techniques for studying the functionality of adipose tissue, and can also be used to test drugs that could combat obesity.

A study highlights the benefits of understanding the behavior of anticoagulant medications. (Article in Spanish)

28/02/18

Pharmaceutical Care has published the results of an observational study conducted by Pharmacology professors from the CEU San Pablo University, which evaluates the relationship between the degree of information that patients treated with oral anticoagulants have about their treatment and the incidence of adverse reactions to it.

XXI Ángel Herrera Awards (Article in Spanish)

29/01/18

The Angel Herrera XXI Awards were presented by the San Pablo CEU University Foundation last Wednesday at an event held at the Casino de Madrid.

The professors from the Faculty of Pharmacy at the CEU San Pablo University, María Calderón Domínguez, Marta Viana Arribas, and Martín Alcalá Díaz-Mor, received the Angel Herrera Award for Best Research Work in the Area of Experimental Sciences for their work ‘Brown adipose tissue bioenergetics: a new methodological approach’. The award was presented by the President and CEO of LG Electronics for Spain and Portugal, Jaime de Jaraiz Lozano.

Marta Gil, awarded for researching in obesity and cardiovascular risk. (Article in Spanish)

28/05/15

Pharmacy PhD and associate professor in the Pharmacology department, Marta Gil Ortega, from the CEU San Pablo University, has been awarded the “Mario Martín Velamazán” Pharmacy Research Award in its fifth edition for her research trajectory in obesity and cardiovascular risk.